You will need to modify config_darwin.py to add the default include and library paths for macports.
Before
incdirs = ['/usr/local/include']
libdirs = ['/usr/local/lib']
After
incdirs = ['/usr/local/include','/opt/local/include']
libdirs = ['/usr/local/lib','/opt/local/lib']
python setup.py bdist_mpkg --open